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Gastrointestinal symptoms accompanying the use of glucagon-like peptide-1 (GLP-1) receptor agonists and glucose-dependent insulinotropic polypeptide receptor-GLP-1 receptor co-agonists have been extensively catalogued. This case report contains a dramatic presentation of unintended consequences from the use of a novel triple-hormone receptor agonist and points toward the need for increased regulatory measures regarding the marketing of these treatments.
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Komolafe, O. (2026). Retatrutide-Induced Intractable Diarrhea. Annals of Internal Medicine Clinical Cases, 5(4). https://doi.org/10.7326/aimcc.2025.1218
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