Abstract & Overview
Atherosclerosis is a chronic inflammation disease that is initiated by endothelial cell injury.Hyperlipidemia is an independent risk factor for atherosclerosis.Oxidized low-density lipoprotein (ox-LDL) is a major component of hyperlipidemia and contributes to atherosclerosis.Ox-LDL and ox-LDLrelated reactive oxygen species (ROS) and inflammation have deleterious effects on vascular endothelial cells.Previous studies have demonstrated that thioredoxin-1 (Trx) is one of the key regulators of intracellular redox, which may play a role in the pathogenesis of atherosclerosis.This review will summarize the protective mechanisms of Trx on endothelial injury induced by ox-LDL.