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Although mitochondrial disease is usually associated with reductions in electron transport chain complex activity, a few reports have associated mitochondrial disease with complex overactivity. This is the first report to associate complex IV overact
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Naviaux, R. K., & Frye, R. E. (2015). Autistic disorder with complex IV overactivity: A new mitochondrial syndrome. Journal of Pediatric Neurology, 09(04), 427–434. https://doi.org/10.3233/jpn-2011-0507
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