Flat-plate PV-Thermal collectors and systems: A review
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Candida species are fungal pathogens known for their ability to cause superficial and systemic infections in the human host. These pathogens are able to persist inside the host due to the development of pathogenicity and multidrug resistance traits, often leading to the failure of therapeutic strategies. One specific feature of Candida species pathogenicity is their ability to form biofilms, which protects them from external factors such as host immune system defences and antifungal drugs. This review focuses on the current threats and challenges when dealing with biofilms formed by Candida albicans, Candida glabrata, Candida tropicalis and Candida parapsilosis, highlighting the differences between the four species. Biofilm characteristics depend on the ability of each species to produce extracellular polymeric substances (EPS) and display dimorphic growth, but also on the biofilm substratum, carbon source and other factors. Additionally, the transcriptional control over processes like adhesion, biofilm formation, filamentation and EPS production displays great complexity and diversity within pathogenic yeasts of the Candida genus. These differences not only have implications in the persistence of colonization and infections, but also on antifungal resistance typically found in Candida biofilm cells, potentiated by EPS, that functions as a barrier to drug diffusion, and by the overexpression of drug resistance transporters. The ability to interact with different species in in vivo Candida biofilms is also a key factor to consider when dealing with this problem. Despite many challenges, the most promising strategies that are currently available or under development to limit biofilm formation or to eradicate mature biofilms are discussed.
Methods of instruction which are intended to facilitate understanding tend to incorporate all the information elements required for understanding in the instructions. Frequently, these types of instructions may overwhelm a learner's limited working memory and hinder learning. In four experiments, a two-phase, isolated-interacting elements learning approach was developed in which in the first phase, the element interactivity of complex material was artificially reduced by presenting the material as isolated elements of information that could be processed serially, rather than simultaneously, in working memory. In the second phase, all the information for understanding was presented. The control group was simply presented with all the information for understanding in both Phases 1 and 2. The results provided powerful evidence that for certain groups of learners, information is better learnt through the isolated-interacting elements instructional method.
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Water is the key resource limiting world agricultural production. Although an impressive number of research reports have been published on plant drought tolerance enhancement via genetic modifications during the last few years, progress has been slower than expected. We suggest a feasible alternative strategy by application of rhizospheric bacteria coevolved with plant roots in harsh environments over millions of years, and harboring adaptive traits improving plant fitness under biotic and abiotic stresses. We show the effect of bacterial priming on wheat drought stress tolerance enhancement, resulting in up to 78% greater plant biomass and five-fold higher survivorship under severe drought. We monitored emissions of seven stress-related volatiles from bacterially-primed drought-stressed wheat seedlings, and demonstrated that three of these volatiles are likely promising candidates for a rapid non-invasive technique to assess crop drought stress and its mitigation in early phases of stress development. We conclude that gauging stress by elicited volatiles provides an effectual platform for rapid screening of potent bacterial strains and that priming with isolates of rhizospheric bacteria from harsh environments is a promising, novel way to improve plant water use efficiency. These new advancements importantly contribute towards solving food security issues in changing climates.
The Augmented Reality (AR) technology enhances the human perception of the world by combining the real environment with the virtual space. With the explosive growth of powerful, less expensive mobile devices, and the emergence of sophisticated communication infrastructure, Mobile Augmented Reality (MAR) applications are gaining increased popularity. MAR allows users to run AR applications on mobile devices with greater mobility and at a lower cost. The emerging 5G communication technologies act as critical enablers for future MAR applications to achieve ultra-low latency and extremely high data rates while Multi-access Edge Computing (MEC) brings enhanced computational power closer to the users to complement MAR. This paper extensively discusses the landscape of MAR through the past and its future prospects with respect to the 5G systems and complementary technology MEC. The paper especially provides an informative analysis of the network formation of current and future MAR systems in terms of cloud, edge, localized, and hybrid architectural options. The paper discusses key application areas for MAR and their future with the advent of 5G technologies. The paper also discusses the requirements and limitations of MAR technical aspects such as communication, mobility management, energy management, service offloading and migration, security, and privacy and analyzes the role of 5G technologies.
Smart city is a collective term for technologies and concepts that are directed toward making cities efficient, technologically more advanced, greener and more socially inclusive. These concepts include technical, economic and social innovations. This term has been tossed around by various actors in politics, business, administration and urban planning since the 2000s to establish tech-based changes and innovations in urban areas. The idea of the smart city is used in conjunction with the utilization of digital technologies and at the same time represents a reaction to the economic, social and political challenges that post-industrial societies are confronted with at the start of the new millennium. The key focus is on dealing with challenges faced by urban society, such as environmental pollution, demographic change, population growth, healthcare, the financial crisis or scarcity of resources. In a broader sense, the term also includes non-technical innovations that make urban life more sustainable. So far, the idea of using IoT-based sensor networks for healthcare applications is a promising one with the potential of minimizing inefficiencies in the existing infrastructure. A machine learning approach is key to successful implementation of the IoT-powered wireless sensor networks for this purpose since there is large amount of data to be handled intelligently. Throughout this paper, it will be discussed in detail how AI-powered IoT and WSNs are applied in the healthcare sector. This research will be a baseline study for understanding the role of the IoT in smart cities, in particular in the healthcare sector, for future research works.
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This paper reviews state-of-the-art research solutions across the spectrum of medical imaging informatics, discusses clinical translation, and provides future directions for advancing clinical practice. More specifically, it summarizes advances in medical imaging acquisition technologies for different modalities, highlighting the necessity for efficient medical data management strategies in the context of AI in big healthcare data analytics. It then provides a synopsis of contemporary and emerging algorithmic methods for disease classification and organ/ tissue segmentation, focusing on AI and deep learning architectures that have already become the de facto approach. The clinical benefits of in-silico modelling advances linked with evolving 3D reconstruction and visualization applications are further documented. Concluding, integrative analytics approaches driven by associate research branches highlighted in this study promise to revolutionize imaging informatics as known today across the healthcare continuum for both radiology and digital pathology applications. The latter, is projected to enable informed, more accurate diagnosis, timely prognosis, and effective treatment planning, underpinning precision medicine.
Today, around 54% of the world’s population lives in urban areas. By 2050, this share is expected to go up significantly. As a result, city logistics, which focuses on the efficient and effective transportation of goods in urban areas while taking into account the negative effects on congestion, safety, and environment, is critical to ensuring continued quality of life in cities. We review and discuss a variety of current and anticipated challenges and opportunities of city logistics. We hope this helps shaping an appropriate research agenda and stimulates more researchers to enter this exciting field.
Abstract Conversion of waste heat to voltage has the potential to significantly reduce the carbon footprint of a number of critical energy sectors, such as the transportation and electricity‐generation sectors, and manufacturing processes. Thermal energy is also an abundant low‐flux source that can be harnessed to power portable/wearable electronic devices and critical components in remote off‐grid locations. As such, a number of different inorganic and organic materials are being explored for their potential in thermoelectric‐energy‐harvesting devices. Carbon‐based thermoelectric materials are particularly attractive due to their use of nontoxic, abundant source‐materials, their amenability to high‐throughput solution‐phase fabrication routes, and the high specific energy (i.e., W g −1 ) enabled by their low mass. Single‐walled carbon nanotubes (SWCNTs) represent a unique 1D carbon allotrope with structural, electrical, and thermal properties that enable efficient thermoelectric‐energy conversion. Here, the progress made toward understanding the fundamental thermoelectric properties of SWCNTs, nanotube‐based composites, and thermoelectric devices prepared from these materials is reviewed in detail. This progress illuminates the tremendous potential that carbon‐nanotube‐based materials and composites have for producing high‐performance next‐generation devices for thermoelectric‐energy harvesting.
BACKGROUND: Mobile phone sensors can be used to develop context-aware systems that automatically detect when patients require assistance. Mobile phones can also provide ecological momentary interventions that deliver tailored assistance during problematic situations. However, such approaches have not yet been used to treat major depressive disorder. OBJECTIVE: The purpose of this study was to investigate the technical feasibility, functional reliability, and patient satisfaction with Mobilyze!, a mobile phone- and Internet-based intervention including ecological momentary intervention and context sensing. METHODS: We developed a mobile phone application and supporting architecture, in which machine learning models (ie, learners) predicted patients' mood, emotions, cognitive/motivational states, activities, environmental context, and social context based on at least 38 concurrent phone sensor values (eg, global positioning system, ambient light, recent calls). The website included feedback graphs illustrating correlations between patients' self-reported states, as well as didactics and tools teaching patients behavioral activation concepts. Brief telephone calls and emails with a clinician were used to promote adherence. We enrolled 8 adults with major depressive disorder in a single-arm pilot study to receive Mobilyze! and complete clinical assessments for 8 weeks. RESULTS: Promising accuracy rates (60% to 91%) were achieved by learners predicting categorical contextual states (eg, location). For states rated on scales (eg, mood), predictive capability was poor. Participants were satisfied with the phone application and improved significantly on self-reported depressive symptoms (beta(week) = -.82, P < .001, per-protocol Cohen d = 3.43) and interview measures of depressive symptoms (beta(week) = -.81, P < .001, per-protocol Cohen d = 3.55). Participants also became less likely to meet criteria for major depressive disorder diagnosis (b(week) = -.65, P = .03, per-protocol remission rate = 85.71%). Comorbid anxiety symptoms also decreased (beta(week) = -.71, P < .001, per-protocol Cohen d = 2.58). CONCLUSIONS: Mobilyze! is a scalable, feasible intervention with preliminary evidence of efficacy. To our knowledge, it is the first ecological momentary intervention for unipolar depression, as well as one of the first attempts to use context sensing to identify mental health-related states. Several lessons learned regarding technical functionality, data mining, and software development process are discussed. TRIAL REGISTRATION: Clinicaltrials.gov NCT01107041; http://clinicaltrials.gov/ct2/show/NCT01107041 (Archived by WebCite at http://www.webcitation.org/60CVjPH0n).
Bacterial biofilms are complex microbial communities encased in extracellular polymeric substances. Their formation is a multi-step process. Biofilms are a significant problem in treating bacterial infections and are one of the main reasons for the persistence of infections. They can exhibit increased resistance to classical antibiotics and cause disease through device-related and non-device (tissue) -associated infections, posing a severe threat to global health issues. Therefore, early detection and search for new and alternative treatments are essential for treating and suppressing biofilm-associated infections. In this paper, we systematically reviewed the formation of bacterial biofilms, associated infections, detection methods, and potential treatment strategies, aiming to provide researchers with the latest progress in the detection and treatment of bacterial biofilms.
This article addresses educational challenges posed by the future of work, examining “21st century skills”, their conception, assessment, and valorization. It focuses in particular on key soft skill competencies known as the “4Cs”: creativity, critical thinking, collaboration, and communication. In a section on each C, we provide an overview of assessment at the level of individual performance, before focusing on the less common assessment of systemic support for the development of the 4Cs that can be measured at the institutional level (i.e., in schools, universities, professional training programs, etc.). We then present the process of official assessment and certification known as “labelization”, suggesting it as a solution both for establishing a publicly trusted assessment of the 4Cs and for promoting their cultural valorization. Next, two variations of the “International Institute for Competency Development’s 21st Century Skills Framework” are presented. The first of these comprehensive systems allows for the assessment and labelization of the extent to which development of the 4Cs is supported by a formal educational program or institution. The second assesses informal educational or training experiences, such as playing a game. We discuss the overlap between the 4Cs and the challenges of teaching and institutionalizing them, both of which may be assisted by adopting a dynamic interactionist model of the 4Cs—playfully entitled “Crea-Critical-Collab-ication”—for pedagogical and policy-promotion purposes. We conclude by briefly discussing opportunities presented by future research and new technologies such as artificial intelligence and virtual reality.
Emotion recognition from speech signals is an important but challenging component of Human-Computer Interaction (HCI). In the literature of speech emotion recognition (SER), many techniques have been utilized to extract emotions from signals, including many well-established speech analysis and classification techniques. Deep Learning techniques have been recently proposed as an alternative to traditional techniques in SER. This paper presents an overview of Deep Learning techniques and discusses some recent literature where these methods are utilized for speech-based emotion recognition. The review covers databases used, emotions extracted, contributions made toward speech emotion recognition and limitations related to it.
Explainable recommendation attempts to develop models that generate not only high-quality recommendations but also intuitive explanations. The explanations may either be post-hoc or directly come from an explainable model (also called interpretable or transparent model in some contexts). Explainable recommendation tries to address the problem of why: by providing explanations to users or system designers, it helps humans to understand why certain items are recommended by the algorithm, where the human can either be users or system designers. Explainable recommendation helpsendation systems. It also facilitates system design to improve the transparency, persuasiveness, effectiveness, trustworthiness, and satisfaction of recommers for better system debugging. In recent years, a large number of explainable recommendation approaches – especially model-based methods – have been proposed and applied in real-world systems. In this survey, we provide a comprehensive review for the explainable recommendation research. We first highlight the position of explainable recommendation in recommender system research by categorizing recommendation problems into the 5W, i.e., what, when, who, where, and why. We then conduct a comprehensive survey of explainable recommendation on three perspectives: 1) We provide a chronological research timeline of explainable recommendation, including user study approaches in the early years and more recent model-based approaches. 2) We provide a two-dimensional taxonomy to classify existing explainable recommendation research: one dimension is the information source (or display style) of the explanations, and the other dimension is the algorithmic mechanism to generate explainable recommendations. 3) We summarize how explainable recommendation applies to different recommendation tasks, such as product recommendation, social recommendation, and POI recommendation. We also devote a section to discuss the explanation perspectives in broader IR and AI/ML research. We end the survey by discussing potential future directions to promote the explainable recommendation research area and beyond.
Purpose The purpose of this paper is to consolidate the servitization knowledge base from an organizational change perspective, identifying developed, developing and undeveloped topics to provide a platform that directs future research. Design/methodology/approach This paper addresses three objectives: it comprehensively examines organizational change management literature for selection of a theoretical framework; it classifies extant studies within the framework through a systemic literature review; and it analyses 232 selected papers and proposes a research agenda. Findings Analysis suggests increasing global awareness of the importance of services to manufacturers. However, some topics, especially related to servitization transformation, remain undeveloped. Research limitations/implications Although the authors tried to include all publications relevant to servitization, some might not have been captured. Evaluation and interpretation relied on the research team and subsequent research workshops. Practical implications One of the most significant challenges for practitioners of servitization is how to transform a manufacturing organization to exploit the opportunity. This paper consolidates literature regarding servitization, identifying progress concerning key research topics and contributing a platform for future research. The goal is to inform research to result eventually in a roadmap for practitioners seeking to servitize. Originality/value Although extant reviews of servitization identify themes that are examined well, they struggle to identify unanswered questions. This paper addresses this gap by focusing on servitization as a process of organizational change.
BACKGROUND: Immune infiltration of breast tumours is associated with clinical outcome. However, past work has not accounted for the diversity of functionally distinct cell types that make up the immune response. The aim of this study was to determine whether differences in the cellular composition of the immune infiltrate in breast tumours influence survival and treatment response, and whether these effects differ by molecular subtype. METHODS AND FINDINGS: We applied an established computational approach (CIBERSORT) to bulk gene expression profiles of almost 11,000 tumours to infer the proportions of 22 subsets of immune cells. We investigated associations between each cell type and survival and response to chemotherapy, modelling cellular proportions as quartiles. We found that tumours with little or no immune infiltration were associated with different survival patterns according to oestrogen receptor (ER) status. In ER-negative disease, tumours lacking immune infiltration were associated with the poorest prognosis, whereas in ER-positive disease, they were associated with intermediate prognosis. Of the cell subsets investigated, T regulatory cells and M0 and M2 macrophages emerged as the most strongly associated with poor outcome, regardless of ER status. Among ER-negative tumours, CD8+ T cells (hazard ratio [HR] = 0.89, 95% CI 0.80-0.98; p = 0.02) and activated memory T cells (HR 0.88, 95% CI 0.80-0.97; p = 0.01) were associated with favourable outcome. T follicular helper cells (odds ratio [OR] = 1.34, 95% CI 1.14-1.57; p < 0.001) and memory B cells (OR = 1.18, 95% CI 1.0-1.39; p = 0.04) were associated with pathological complete response to neoadjuvant chemotherapy in ER-negative disease, suggesting a role for humoral immunity in mediating response to cytotoxic therapy. Unsupervised clustering analysis using immune cell proportions revealed eight subgroups of tumours, largely defined by the balance between M0, M1, and M2 macrophages, with distinct survival patterns by ER status and associations with patient age at diagnosis. The main limitations of this study are the use of diverse platforms for measuring gene expression, including some not previously used with CIBERSORT, and the combined analysis of different forms of follow-up across studies. CONCLUSIONS: Large differences in the cellular composition of the immune infiltrate in breast tumours appear to exist, and these differences are likely to be important determinants of both prognosis and response to treatment. In particular, macrophages emerge as a possible target for novel therapies. Detailed analysis of the cellular immune response in tumours has the potential to enhance clinical prediction and to identify candidates for immunotherapy.
Urban agriculture offers an alternative land use for integrating multiple functions in densely populated areas. While urban agriculture has historically been an important element of cities in many developing countries, recent concerns about economic and food security have resulted in a growing movement to produce food in cities of developed countries including the United States. In these regions, urban agriculture offers a new frontier for land use planners and landscape designers to become involved in the development and transformation of cities to support community farms, allotment gardens, rooftop gardening, edible landscaping, urban forests, and other productive features of the urban environment. Despite the growing interest in urban agriculture, urban planners and landscape designers are often ill-equipped to integrate food-systems thinking into future plans for cities. The challenge (and opportunity) is to design urban agriculture spaces to be multifunctional, matching the specific needs and preferences of local residents, while also protecting the environment. This paper provides a review of the literature on urban agriculture as it applies to land use planning in the United States. The background includes a brief historical perspective of urban agriculture around the world, as well as more recent examples in the United States. Land use applications are considered for multiple scales, from efforts that consider an entire city, to those that impact a single building or garden. Barriers and constraints to urban agriculture are discussed, followed by research opportunities and methodological approaches that might be used to address them. This work has implications for urban planners, landscape designers, and extension agents, as opportunities to integrate urban agriculture into the fabric of our cities expand.
The COVID-19 pandemic has exposed an interconnected and tightly coupled globalized world in rapid change. This article sets the scientific stage for understanding and responding to such change for global sustainability and resilient societies. We provide a systemic overview of the current situation where people and nature are dynamically intertwined and embedded in the biosphere, placing shocks and extreme events as part of this dynamic; humanity has become the major force in shaping the future of the Earth system as a whole; and the scale and pace of the human dimension have caused climate change, rapid loss of biodiversity, growing inequalities, and loss of resilience to deal with uncertainty and surprise. Taken together, human actions are challenging the biosphere foundation for a prosperous development of civilizations. The Anthropocene reality-of rising system-wide turbulence-calls for transformative change towards sustainable futures. Emerging technologies, social innovations, broader shifts in cultural repertoires, as well as a diverse portfolio of active stewardship of human actions in support of a resilient biosphere are highlighted as essential parts of such transformations.
Wireless sensor networks (WSNs) can be used in agriculture to provide farmers with a large amount of information. Precision agriculture (PA) is a management strategy that employs information technology to improve quality and production. Utilizing wireless sensor technologies and management tools can lead to a highly effective, green agriculture. Based on PA management, the same routine to a crop regardless of site environments can be avoided. From several perspectives, field management can improve PA, including the provision of adequate nutrients for crops and the wastage of pesticides for the effective control of weeds, pests, and diseases. This review outlines the recent applications of WSNs in agriculture research as well as classifies and compares various wireless communication protocols, the taxonomy of energy-efficient and energy harvesting techniques for WSNs that can be used in agricultural monitoring systems, and comparison between early research works on agriculture-based WSNs. The challenges and limitations of WSNs in the agricultural domain are explored, and several power reduction and agricultural management techniques for long-term monitoring are highlighted. These approaches may also increase the number of opportunities for processing Internet of Things (IoT) data.
This research investigated the relation between individual differences in inhibitory control and emotion regulation. Preschool children ( N = 53) ages 4–6 ( M = 5; 0) were assessed on brief batteries of inhibitory control of prepotent responses and emotion regulation. Individual differences in inhibitory control were significantly correlated with children's ability to regulate their emotions. This relation held up even after controlling for age and verbal ability, and persisted for both Emotion Understanding and “online” control of emotional expressions that were negative (Disappointing Gift) or positive (Secret Keeping). Parent report of children's self-control and emotion regulation corroborated the behavioral results. These findings suggest that executive control of attention, action, and emotion are skills that develop in concert in the preschool period. However, there was also evidence of a quadratic relation in which emotion regulation was optimal at intermediate levels of inhibition, highlighting the interplay of both cognitive control and temperament in socio-emotional functioning.
Finding a good join order is crucial for query performance. In this paper, we introduce the Join Order Benchmark (JOB) and experimentally revisit the main components in the classic query optimizer architecture using a complex, real-world data set and realistic multi-join queries. We investigate the quality of industrial-strength cardinality estimators and find that all estimators routinely produce large errors. We further show that while estimates are essential for finding a good join order, query performance is unsatisfactory if the query engine relies too heavily on these estimates. Using another set of experiments that measure the impact of the cost model, we find that it has much less influence on query performance than the cardinality estimates. Finally, we investigate plan enumeration techniques comparing exhaustive dynamic programming with heuristic algorithms and find that exhaustive enumeration improves performance despite the sub-optimal cardinality estimates.