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in Architecture & Planning
Periodicals

Digital Twin: Vision, Benefits, Boundaries, and Creation for Buildings

The concept of a digital twin has been used in some industries where an accurate digital model of the equipment can be used for predictive maintenance. The use of a digital twin for performance is critical, and for capital-intensive equipment such as jet engines it proved to be successful in terms of cost savings and reliability improvements. In this paper, we aim to study the expansion of the digital twin in including building life cycle management and explore the benefits and shortcomings of such implementation. In four rounds of experimentation, more than 25,000 sensor reading instances were collected, analyzed, and utilized to create and test a limited digital twin of an office building facade element. This is performed to point out the method of implementation, highlight the benefits gained from digital twin, and to uncover some of the technical shortcomings of the current Internet of Things systems for this purpose.

Architecture & Planning• 2019• Institute of Electrical and Electronics Engineers
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Urban Digital Twins for Smart Cities and Citizens: The Case Study of Herrenberg, Germany

Cities are complex systems connected to economic, ecological, and demographic conditions and change. They are also characterized by diverging perceptions and interests of citizens and stakeholders. Thus, in the arena of urban planning, we are in need of approaches that are able to cope not only with urban complexity but also allow for participatory and collaborative processes to empower citizens. This to create democratic cities. Connected to the field of smart cities and citizens, we present in this paper, the prototype of an urban digital twin for the 30,000-people town of Herrenberg in Germany. Urban digital twins are sophisticated data models allowing for collaborative processes. The herein presented prototype comprises (1) a 3D model of the built environment, (2) a street network model using the theory and method of space syntax, (3) an urban mobility simulation, (4) a wind flow simulation, and (5) a number of empirical quantitative and qualitative data using volunteered geographic information (VGI). In addition, the urban digital twin was implemented in a visualization platform for virtual reality and was presented to the general public during diverse public participatory processes, as well as in the framework of the “Morgenstadt Werkstatt” (Tomorrow’s Cities Workshop). The results of a survey indicated that this method and technology could significantly aid in participatory and collaborative processes. Further understanding of how urban digital twins support urban planners, urban designers, and the general public as a collaboration and communication tool and for decision support allows us to be more intentional when creating smart cities and sustainable cities with the help of digital twins. We conclude the paper with a discussion of the presented results and further research directions.

Architecture & Planning• 2020• Multidisciplinary Digital Publishing Institute
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DSPSR: Digital Signal Processing Software for Pulsar Astronomy

Abstract dspsr is a high-performance, open-source, object-oriented, digital signal processing software library and application suite for use in radio pulsar astronomy. Written primarily in C++, the library implements an extensive range of modular algorithms that can optionally exploit both multiple-core processors and general-purpose graphics processing units. After over a decade of research and development, dspsr is now stable and in widespread use in the community. This paper presents a detailed description of its functionality, justification of major design decisions, analysis of phase-coherent dispersion removal algorithms, and demonstration of performance on some contemporary microprocessor architectures.

Architecture & Planning• 2011• Cambridge University Press
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Antibiotic Resistance: One Health One World Outlook

Antibiotic resistance (ABR) is a growing public health concern worldwide, and it is now regarded as a critical One Health issue. One Health's interconnected domains contribute to the emergence, evolution, and spread of antibiotic-resistant microorganisms on a local and global scale, which is a significant risk factor for global health. The persistence and spread of resistant microbial species, and the association of determinants at the human-animal-environment interface can alter microbial genomes, resulting in resistant superbugs in various niches. ABR is motivated by a well-established link between three domains: human, animal, and environmental health. As a result, addressing ABR through the One Health approach makes sense. Several countries have implemented national action plans based on the One Health approach to combat antibiotic-resistant microbes, following the Tripartite's Commitment Food and Agriculture Organization (FAO)-World Organization for Animal Health (OIE)-World Health Organization (WHO) guidelines. The ABR has been identified as a global health concern, and efforts are being made to mitigate this global health threat. To summarize, global interdisciplinary and unified approaches based on One Health principles are required to limit the ABR dissemination cycle, raise awareness and education about antibiotic use, and promote policy, advocacy, and antimicrobial stewardship.

Architecture & Planning• 2021• Frontiers Media
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Structure-Based Virtual Screening: From Classical to Artificial Intelligence

The drug development process is a major challenge in the pharmaceutical industry since it takes a substantial amount of time and money to move through all the phases of developing of a new drug. One extensively used method to minimize the cost and time for the drug development process is computer-aided drug design (CADD). CADD allows better focusing on experiments, which can reduce the time and cost involved in researching new drugs. In this context, structure-based virtual screening (SBVS) is robust and useful and is one of the most promising in silico techniques for drug design. SBVS attempts to predict the best interaction mode between two molecules to form a stable complex, and it uses scoring functions to estimate the force of noncovalent interactions between a ligand and molecular target. Thus, scoring functions are the main reason for the success or failure of SBVS software. Many software programs are used to perform SBVS, and since they use different algorithms, it is possible to obtain different results from different software using the same input. In the last decade, a new technique of SBVS called consensus virtual screening (CVS) has been used in some studies to increase the accuracy of SBVS and to reduce the false positives obtained in these experiments. An indispensable condition to be able to utilize SBVS is the availability of a 3D structure of the target protein. Some virtual databases, such as the Protein Data Bank, have been created to store the 3D structures of molecules. However, sometimes it is not possible to experimentally obtain the 3D structure. In this situation, the homology modeling methodology allows the prediction of the 3D structure of a protein from its amino acid sequence. This review presents an overview of the challenges involved in the use of CADD to perform SBVS, the areas where CADD tools support SBVS, a comparison between the most commonly used tools, and the techniques currently used in an attempt to reduce the time and cost in the drug development process. Finally, the final considerations demonstrate the importance of using SBVS in the drug development process.

Architecture & Planning• 2020• Frontiers Media
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Evolution of Non-Terrestrial Networks From 5G to 6G: A Survey

Non-terrestrial networks (NTNs) traditionally have certain limited applications. However, the recent technological advancements and manufacturing cost reduction opened up myriad applications of NTNs for 5G and beyond networks, especially when integrated into terrestrial networks (TNs). This article comprehensively surveys the evolution of NTNs highlighting their relevance to 5G networks and essentially, how it will play a pivotal role in the development of 6G ecosystem. We discuss important features of NTNs integration into TNs and the synergies by delving into the new range of services and use cases, various architectures, technological enablers, and higher layer aspects pertinent to NTNs integration. Moreover, we review the corresponding challenges arising from the technical peculiarities and the new approaches being adopted to develop efficient integrated ground-air-space (GAS) networks. Our survey further includes the major progress and outcomes from academic research as well as industrial efforts representing the main industrial trends, field trials, and prototyping towards the 6G networks.

Architecture & Planning• 2022• Institute of Electrical and Electronics Engineers
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Wind Turbine Condition Monitoring: State-of-the-Art Review, New Trends, and Future Challenges

As the demand for wind energy continues to grow at exponential rates, reducing operation and maintenance (OM) costs and improving reliability have become top priorities in wind turbine (WT) maintenance strategies. In addition to the development of more highly evolved WT designs intended to improve availability, the application of reliable and cost-effective condition-monitoring (CM) techniques offers an efficient approach to achieve this goal. This paper provides a general review and classification of wind turbine condition monitoring (WTCM) methods and techniques with a focus on trends and future challenges. After highlighting the relevant CM, diagnosis, and maintenance analysis, this work outlines the relationship between these concepts and related theories, and examines new trends and future challenges in the WTCM industry. Interesting insights from this research are used to point out strengths and weaknesses in today’s WTCM industry and define research priorities needed for the industry to meet the challenges in wind industry technological evolution and market growth.

Architecture & Planning• 2014• Multidisciplinary Digital Publishing Institute
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The SAIL Databank: building a national architecture for e-health research and evaluation

BACKGROUND: Vast quantities of electronic data are collected about patients and service users as they pass through health service and other public sector organisations, and these data present enormous potential for research and policy evaluation. The Health Information Research Unit (HIRU) aims to realise the potential of electronically-held, person-based, routinely-collected data to conduct and support health-related studies. However, there are considerable challenges that must be addressed before such data can be used for these purposes, to ensure compliance with the legislation and guidelines generally known as Information Governance. METHODS: A set of objectives was identified to address the challenges and establish the Secure Anonymised Information Linkage (SAIL) system in accordance with Information Governance. These were to: 1) ensure data transportation is secure; 2) operate a reliable record matching technique to enable accurate record linkage across datasets; 3) anonymise and encrypt the data to prevent re-identification of individuals; 4) apply measures to address disclosure risk in data views created for researchers; 5) ensure data access is controlled and authorised; 6) establish methods for scrutinising proposals for data utilisation and approving output; and 7) gain external verification of compliance with Information Governance. RESULTS: The SAIL databank has been established and it operates on a DB2 platform (Data Warehouse Edition on AIX) running on an IBM 'P' series Supercomputer: Blue-C. The findings of an independent internal audit were favourable and concluded that the systems in place provide adequate assurance of compliance with Information Governance. This expanding databank already holds over 500 million anonymised and encrypted individual-level records from a range of sources relevant to health and well-being. This includes national datasets covering the whole of Wales (approximately 3 million population) and local provider-level datasets, with further growth in progress. The utility of the databank is demonstrated by increasing engagement in high quality research studies. CONCLUSION: Through the pragmatic approach that has been adopted, we have been able to address the key challenges in establishing a national databank of anonymised person-based records, so that the data are available for research and evaluation whilst meeting the requirements of Information Governance.

Architecture & Planning• 2009• BioMed Central
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The Power of Generative AI: A Review of Requirements, Models, Input–Output Formats, Evaluation Metrics, and Challenges

Generative artificial intelligence (AI) has emerged as a powerful technology with numerous applications in various domains. There is a need to identify the requirements and evaluation metrics for generative AI models designed for specific tasks. The purpose of the research aims to investigate the fundamental aspects of generative AI systems, including their requirements, models, input–output formats, and evaluation metrics. The study addresses key research questions and presents comprehensive insights to guide researchers, developers, and practitioners in the field. Firstly, the requirements necessary for implementing generative AI systems are examined and categorized into three distinct categories: hardware, software, and user experience. Furthermore, the study explores the different types of generative AI models described in the literature by presenting a taxonomy based on architectural characteristics, such as variational autoencoders (VAEs), generative adversarial networks (GANs), diffusion models, transformers, language models, normalizing flow models, and hybrid models. A comprehensive classification of input and output formats used in generative AI systems is also provided. Moreover, the research proposes a classification system based on output types and discusses commonly used evaluation metrics in generative AI. The findings contribute to advancements in the field, enabling researchers, developers, and practitioners to effectively implement and evaluate generative AI models for various applications. The significance of the research lies in understanding that generative AI system requirements are crucial for effective planning, design, and optimal performance. A taxonomy of models aids in selecting suitable options and driving advancements. Classifying input–output formats enables leveraging diverse formats for customized systems, while evaluation metrics establish standardized methods to assess model quality and performance.

Architecture & Planning• 2023• Multidisciplinary Digital Publishing Institute
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Subsistence strategies in traditional societies distinguish gut microbiomes

Recent studies suggest that gut microbiomes of urban-industrialized societies are different from those of traditional peoples. Here we examine the relationship between lifeways and gut microbiota through taxonomic and functional potential characterization of faecal samples from hunter-gatherer and traditional agriculturalist communities in Peru and an urban-industrialized community from the US. We find that in addition to taxonomic and metabolic differences between urban and traditional lifestyles, hunter-gatherers form a distinct sub-group among traditional peoples. As observed in previous studies, we find that Treponema are characteristic of traditional gut microbiomes. Moreover, through genome reconstruction (2.2-2.5 MB, coverage depth × 26-513) and functional potential characterization, we discover these Treponema are diverse, fall outside of pathogenic clades and are similar to Treponema succinifaciens, a known carbohydrate metabolizer in swine. Gut Treponema are found in non-human primates and all traditional peoples studied to date, suggesting they are symbionts lost in urban-industrialized societies.

Architecture & Planning• 2015• Nature Portfolio
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A Survey of COVID-19 Contact Tracing Apps

The recent outbreak of COVID-19 has taken the world by surprise, forcing lockdowns and straining public health care systems. COVID-19 is known to be a highly infectious virus, and infected individuals do not initially exhibit symptoms, while some remain asymptomatic. Thus, a non-negligible fraction of the population can, at any given time, be a hidden source of transmissions. In response, many governments have shown great interest in smartphone contact tracing apps that help automate the difficult task of tracing all recent contacts of newly identified infected individuals. However, tracing apps have generated much discussion around their key attributes, including system architecture, data management, privacy, security, proximity estimation, and attack vulnerability. In this article, we provide the first comprehensive review of these much-discussed tracing app attributes. We also present an overview of many proposed tracing app examples, some of which have been deployed countrywide, and discuss the concerns users have reported regarding their usage. We close by outlining potential research directions for next-generation app design, which would facilitate improved tracing and security performance, as well as wide adoption by the population at large.

Architecture & Planning• 2020• Institute of Electrical and Electronics Engineers
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How language production shapes language form and comprehension

Language production processes can provide insight into how language comprehension works and language typology-why languages tend to have certain characteristics more often than others. Drawing on work in memory retrieval, motor planning, and serial order in action planning, the Production-Distribution-Comprehension (PDC) account links work in the fields of language production, typology, and comprehension: (1) faced with substantial computational burdens of planning and producing utterances, language producers implicitly follow three biases in utterance planning that promote word order choices that reduce these burdens, thereby improving production fluency. (2) These choices, repeated over many utterances and individuals, shape the distributions of utterance forms in language. The claim that language form stems in large degree from producers' attempts to mitigate utterance planning difficulty is contrasted with alternative accounts in which form is driven by language use more broadly, language acquisition processes, or producers' attempts to create language forms that are easily understood by comprehenders. (3) Language perceivers implicitly learn the statistical regularities in their linguistic input, and they use this prior experience to guide comprehension of subsequent language. In particular, they learn to predict the sequential structure of linguistic signals, based on the statistics of previously-encountered input. Thus, key aspects of comprehension behavior are tied to lexico-syntactic statistics in the language, which in turn derive from utterance planning biases promoting production of comparatively easy utterance forms over more difficult ones. This approach contrasts with classic theories in which comprehension behaviors are attributed to innate design features of the language comprehension system and associated working memory. The PDC instead links basic features of comprehension to a different source: production processes that shape language form.

Architecture & Planning• 2013• Frontiers Media
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COVID-19 Artificial Intelligence Diagnosis Using Only Cough Recordings

Goal:We hypothesized that COVID-19 subjects, especially including asymptomatics, could be accurately discriminated only from a forced-cough cell phone recording using Artificial Intelligence. To train our MIT Open Voice model we built a data collection pipeline of COVID-19 cough recordings through our website (opensigma.mit.edu) between April and May 2020 and created the largest audio COVID-19 cough balanced dataset reported to date with 5,320 subjects.Methods:We developed an AI speech processing framework that leverages acoustic biomarker feature extractors to pre-screen for COVID-19 from cough recordings, and provide a personalized patient saliency map to longitudinally monitor patients in real-time, non-invasively, and at essentially zero variable cost. Cough recordings are transformed with Mel Frequency Cepstral Coefficient and inputted into a Convolutional Neural Network (CNN) based architecture made up of one Poisson biomarker layer and 3 pre-trained ResNet50's in parallel, outputting a binary pre-screening diagnostic. Our CNN-based models have been trained on 4256 subjects and tested on the remaining 1064 subjects of our dataset. Transfer learning was used to learn biomarker features on larger datasets, previously successfully tested in our Lab on Alzheimer's, which significantly improves the COVID-19 discrimination accuracy of our architecture.Results:When validated with subjects diagnosed using an official test, the model achieves COVID-19 sensitivity of 98.5% with a specificity of 94.2% (AUC: 0.97). For asymptomatic subjects it achieves sensitivity of 100% with a specificity of 83.2%.Conclusions:AI techniques can produce a free, non-invasive, real-time, any-time, instantly distributable, large-scale COVID-19 asymptomatic screening tool to augment current approaches in containing the spread of COVID-19. Practical use cases could be for daily screening of students, workers, and public as schools, jobs, and transport reopen, or for pool testing to quickly alert of outbreaks in groups. General speech biomarkers may exist that cover several disease categories, as we demonstrated using the same ones for COVID-19 and Alzheimer's.

Architecture & Planning• 2020• Institute of Electrical and Electronics Engineers
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Unmanned Aerial Vehicles in Agriculture: A Review of Perspective of Platform, Control, and Applications

For agricultural applications, regularized smart-farming solutions are being considered, including the use of unmanned aerial vehicles (UAVs). The UAVs combine information and communication technologies, robots, artificial intelligence, big data, and the Internet of Things. The agricultural UAVs are highly capable, and their use has expanded across all areas of agriculture, including pesticide and fertilizer spraying, seed sowing, and growth assessment and mapping. Accordingly, the market for agricultural UAVs is expected to continue growing with the related technologies. In this study, we consider the latest trends and applications of leading technologies related to agricultural UAVs, control technologies, equipment, and development. We discuss the use of UAVs in real agricultural environments. Furthermore, the future development of the agricultural UAVs and their challenges are presented.

Architecture & Planning• 2019• Institute of Electrical and Electronics Engineers
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Urban Morphology as an emerging interdisciplinary field

The forces and events leading to the formation of the International Seminar on Urban Form (ISUF) are identified. ISUF is expanding the field of urban morphology beyond its original confines in geography, particularly into the domains of architecture and planning. Three schools of urban morphology, in England, Italy and France, are coming together, following seminal work by two morphologists, M.R.G. Conzen and Saverio Muratori. The bringing together of these schools provides the basis for an interdisciplinary field and the opportunity to establish common theoretical foundations for the growing number of urban morphologists in many parts of the world. ISUF's ambitious mission is to address real and timely issues concerning city building by providing a forum for thought and action which includes related disciplines and professions in different cultures. The potential of an interdisciplinary urban morphology to contribute to the understanding and management of urban development in a period of unprecedented change is discussed.

Architecture & Planning• 1997
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Classical Mathematical Models for Description and Prediction of Experimental Tumor Growth

Despite internal complexity, tumor growth kinetics follow relatively simple laws that can be expressed as mathematical models. To explore this further, quantitative analysis of the most classical of these were performed. The models were assessed against data from two in vivo experimental systems: an ectopic syngeneic tumor (Lewis lung carcinoma) and an orthotopically xenografted human breast carcinoma. The goals were threefold: 1) to determine a statistical model for description of the measurement error, 2) to establish the descriptive power of each model, using several goodness-of-fit metrics and a study of parametric identifiability, and 3) to assess the models' ability to forecast future tumor growth. The models included in the study comprised the exponential, exponential-linear, power law, Gompertz, logistic, generalized logistic, von Bertalanffy and a model with dynamic carrying capacity. For the breast data, the dynamics were best captured by the Gompertz and exponential-linear models. The latter also exhibited the highest predictive power, with excellent prediction scores (≥80%) extending out as far as 12 days in the future. For the lung data, the Gompertz and power law models provided the most parsimonious and parametrically identifiable description. However, not one of the models was able to achieve a substantial prediction rate (≥70%) beyond the next day data point. In this context, adjunction of a priori information on the parameter distribution led to considerable improvement. For instance, forecast success rates went from 14.9% to 62.7% when using the power law model to predict the full future tumor growth curves, using just three data points. These results not only have important implications for biological theories of tumor growth and the use of mathematical modeling in preclinical anti-cancer drug investigations, but also may assist in defining how mathematical models could serve as potential prognostic tools in the clinic.

Architecture & Planning• 2014• Public Library of Science
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A history of transhumanist thought

The human desire to acquire new capacities is as ancient as our species itself. We have always sought to expand the boundaries of our existence, be it socially, geographically, or mentally. There is a tendency in at least some individuals always to search for a way around every obstacle and limitation to human life and happiness. Ceremonial burial and preserved fragments of religious writings show that prehistoric humans were disturbed by the death of loved ones. Although the belief in a hereafter was common, this did not preclude efforts to extend one’s earthly life. In the Sumerian Epic of Gilgamesh (approx. 1700 B.C.), a king sets out on a quest for immortality. Gilgamesh learns that there exists a natural means – an herb that grows at the bottom of the sea. 1 He successfully retrieves the plant, but a snake steals it from him before he can eat it. In later times, explorers sought the Fountain of Youth, alchemists labored to concoct the Elixir of Life, and various schools of esoteric Taoism in China strove for physical immortality by way of control over or harmony with the forces of nature. The boundary between mythos and science, between magic and technology, was blurry, and almost all conceivable means to the preservation of life were attempted by somebody or other. Yet while explorers made many interesting discoveries and alchemists invented some useful things, such as new dyes and improvements in metallurgy, the goal of life extension proved elusive. The quest to transcend our natural confines has long been viewed with ambivalence, however. Reining it in is the concept of hubris: that some ambitions are off‐limits and will backfire if pursued. The ancient Greeks exhibited this ambivalence in their mythology. Prometheus stole fire from Zeus and gave it to humans, thereby permanently improving the human condition. Yet for this act he was severely punished by Zeus. The gods are repeatedly

Architecture & Planning• 2005• University of Oxford
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Innovation ecosystems and the pace of substitution: Re‐examining technology S‐curves

Why do some new technologies emerge and quickly supplant incumbent technologies while others take years or decades to take off? We explore this question by presenting a framework that considers both the focal competing technologies as well as the ecosystems in which they are embedded. Within our framework, each episode of technology transition is characterized by the ecosystem emergence challenge that confronts the new technology and the ecosystem extension opportunity that is available to the old technology. We identify four qualitatively distinct regimes with clear predictions for the pace of substitution. Evidence from 10 episodes of technology transitions in the semiconductor lithography equipment industry from 1972 to 2009 offers strong support for our framework. We discuss the implication of our approach for firm strategy. Copyright © 2015 John Wiley & Sons, Ltd.

Architecture & Planning• 2015• Wiley
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Blockchain-Based Dynamic Key Management for Heterogeneous Intelligent Transportation Systems

As modern vehicle and communication technologies advanced apace, people begin to believe that the Intelligent Transportation System (ITS) would be achievable in one decade. ITS introduces information technology to the transportation infrastructures and aims to improve road safety and traffic efficiency. However, security is still a main concern in vehicular communication systems (VCSs). This can be addressed through secured group broadcast. Therefore, secure key management schemes are considered as a critical technique for network security. In this paper, we propose a framework for providing secure key management within the heterogeneous network. The security managers (SMs) play a key role in the framework by capturing the vehicle departure information, encapsulating block to transport keys and then executing rekeying to vehicles within the same security domain. The first part of this framework is a novel network topology based on a decentralized blockchain structure. The blockchain concept is proposed to simplify the distributed key management in heterogeneous VCS domains. The second part of the framework uses the dynamic transaction collection period to further reduce the key transfer time during vehicles handover. Extensive simulations and analysis show the effectiveness and efficiency of the proposed framework, in which the blockchain structure performs better in term of key transfer time than the structure with a central manager, while the dynamic scheme allows SMs to flexibly fit various traffic levels.

Architecture & Planning• 2017• Institute of Electrical and Electronics Engineers
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Artificial Intelligence (AI) and Internet of Medical Things (IoMT) Assisted Biomedical Systems for Intelligent Healthcare

Artificial intelligence (AI) is a modern approach based on computer science that develops programs and algorithms to make devices intelligent and efficient for performing tasks that usually require skilled human intelligence. AI involves various subsets, including machine learning (ML), deep learning (DL), conventional neural networks, fuzzy logic, and speech recognition, with unique capabilities and functionalities that can improve the performances of modern medical sciences. Such intelligent systems simplify human intervention in clinical diagnosis, medical imaging, and decision-making ability. In the same era, the Internet of Medical Things (IoMT) emerges as a next-generation bio-analytical tool that combines network-linked biomedical devices with a software application for advancing human health. In this review, we discuss the importance of AI in improving the capabilities of IoMT and point-of-care (POC) devices used in advanced healthcare sectors such as cardiac measurement, cancer diagnosis, and diabetes management. The role of AI in supporting advanced robotic surgeries developed for advanced biomedical applications is also discussed in this article. The position and importance of AI in improving the functionality, detection accuracy, decision-making ability of IoMT devices, and evaluation of associated risks assessment is discussed carefully and critically in this review. This review also encompasses the technological and engineering challenges and prospects for AI-based cloud-integrated personalized IoMT devices for designing efficient POC biomedical systems suitable for next-generation intelligent healthcare.

Architecture & Planning• 2022• Multidisciplinary Digital Publishing Institute
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Fast parallel image registration on CPU and GPU for diagnostic classification of Alzheimer's disease

Nonrigid image registration is an important, but time-consuming task in medical image analysis. In typical neuroimaging studies, multiple image registrations are performed, i.e., for atlas-based segmentation or template construction. Faster image registration routines would therefore be beneficial. In this paper we explore acceleration of the image registration package elastix by a combination of several techniques: (i) parallelization on the CPU, to speed up the cost function derivative calculation; (ii) parallelization on the GPU building on and extending the OpenCL framework from ITKv4, to speed up the Gaussian pyramid computation and the image resampling step; (iii) exploitation of certain properties of the B-spline transformation model; (iv) further software optimizations. The accelerated registration tool is employed in a study on diagnostic classification of Alzheimer's disease and cognitively normal controls based on T1-weighted MRI. We selected 299 participants from the publicly available Alzheimer's Disease Neuroimaging Initiative database. Classification is performed with a support vector machine based on gray matter volumes as a marker for atrophy. We evaluated two types of strategies (voxel-wise and region-wise) that heavily rely on nonrigid image registration. Parallelization and optimization resulted in an acceleration factor of 4-5x on an 8-core machine. Using OpenCL a speedup factor of 2 was realized for computation of the Gaussian pyramids, and 15-60 for the resampling step, for larger images. The voxel-wise and the region-wise classification methods had an area under the receiver operator characteristic curve of 88 and 90%, respectively, both for standard and accelerated registration. We conclude that the image registration package elastix was substantially accelerated, with nearly identical results to the non-optimized version. The new functionality will become available in the next release of elastix as open source under the BSD license.

Architecture & Planning• 2013• Frontiers Media
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